Figure 1 First-line Treatment Abbreviations: B = bendamustine; C = cyclophosphamide; Cb = chlorambucil; CLL = chronic lymphocytic leukemia; F = fludarabine; Obi = obinutuzumab; Ofa = ofatumumab; R = rituximab. *More advanced age, risk for toxicity, renal impairment, or patient preference; ˆIn case of contraindication for ibrutinib, with Pneumocystic jiroveci pneumonia prophylaxis and cytomegalovirus monitoring; ˆˆIn case of contraindication for both ibrutinib and idelalisib; ∼Take into account decreased toxicity with R versus increased progression-free survival with obi.

Figure 2 Second-line Treatment Abbreviations: B = bendamustine; C = cyclophosphamide; Cb = chlorambucil; CLL = chronic lymphocytic leukemia; F = fludarabine; Obi = obinutuzumab; Ofa = ofatumumab; R = rituximab. *Late relapse: > 24 to 36 months after FCR or BR or > 6 to 12 months after CB anti-CD20 antibody; ˆIn case of contraindication for ibrutinib, with Pneumocystic jiroveci pneumonia prophylaxis and cytomegalovirus monitoring; ∼Only if risk factors for non-relapse mortality (age, World Health Organization Performance Score, comorbidity, No 10/10 human leukocyte antigen-matched donor, female donor for male patients) are low.

These guides were made for the person that is trying to memorize new algorithms and wants a hard copy of the algs to carry around.​ I made these because, as of right now, there are a ton of web and video tutorials out there on the web, but very few of them offer a printable version of their information. So I made it my mission to compile all the best information from various tutorials on easy to read PDF files so you can print them out, write on them, get them dirty, tear them to pieces in frustration, carry them around, and even laminate them (if you've never laminated something, I definitely suggest it often an uncontrollable urge to laminate more things follows). Features • Each guide is designed to contain every algorithm you need to solve the cube, but assumes that you know the basics of how to link them all together • Each guide can be printed out on a single sheet of paper, so they are really easy to carry around • Each guide is in full eye-popping color • I made them with the goal of making the algorithms easy to memorize. To do this, I grouped similar algorithms together, color coded common triggers and have chosen related algorithms whenever possible (e.g.

Solving the 2x2x2 using the Ortega Method. The Ortega Method is an intermediate 2x2 method. It is more efficient than using a 3x3 method but not as advanced as methods like CLL or EG that require a large number of algorithms. Learning to solve the 2x2 using the Ortega method requires very few algorithms and you probably already know most of them. Mainly some information about the Roux method, some algorithms, and other stuff.

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For the J permutation, I chose algorithms that were related for the first entry as opposed to the fastest ones. This only occurs a few times and you will probably still find the faster algorithm listed below.) • You don't need to read English to understand each guide because there are very few words and the words aren't really necessary anyway The Guides Please Note - a full description and key can be found at the full • – Single Page Three Look Last Layer • – The OLL Addition. Each algorithm contains color coded triggers • – Contains the Ortega and Guimond Method • – All the CLLs are organized in columns by their OLL case, then organized in pairs based on the color pattern of the U face.

I've got a working draft that shows how to distinguish each case within the pair on the second page so that you can quickly recognize each of the CLLs • – Contains 2 Pair Edge cases and all Parity Cases • – Contains all last two edges cases with and w/o parity • – a 9 algorithm beginner's guide that doesn't hold your hand but does give you the tools you need to solve the cube • – A beginner's as well as an advanced guide to the megaminx last layer • – How to quickly calculate the day of the week based on a given date Example Screen Shots.